Inhibitors of DNA methyltransferase, typified by 5-aza-2′-deoxycytidine (5-Aza-CdR),
induce the expression of genes transcriptionally down-regulated by de novo methylation in …

Transforming growth factor-β1 (TGF-β1) contributes to tumor invasion and cancer
progression by increasing the motility of tumor cells. To identify genes involved in TGF-β …

Neutrophils respond to infection by degranulation, release of reactive oxygen intermediates,
and secretion of chemokines and cytokines; however, activation of neutrophil transcriptional …

Frzb is a newly discovered family of secreted glycoproteins that function to modulate
signaling activity of Wnt. Frzb proteins share sequence homology with the extracellular …

GADD45β regulates cell growth, differentiation, and cell death following cellular exposure to
diverse stimuli, including DNA damage and transforming growth factor-β (TGFβ). We …

MOTIVATION: As sequence databases grow rapidly, results from sequence comparison
searches using fast search methods such as BLAST and FASTA tend to be long and difficult …

In this study we describe a new information resource that provides integrated access to
information on IMAGE (integrated molecular analysis of genomes and their expression) …

Motivation: Blast programs are very efficient in finding relatively strong similarities but some
very distantly related sequences are given a very high Expect value and are ranked very low …

Motivation: More and more often, a gene is epitomized by a large number of sequences in
GenBank. This high redundancy makes it very difficult to identify a unique best match for a …

ABSTRACT PFAM is a database of multiple alignments and hidden Markov models (HMMs)
of common, conserved protein domains. PFAM HMMs complement BLAST analysis in the …