Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

The recent accelerated approval for use in extensively drug-resistant and multidrug-resistant-
tuberculosis (MDR-TB) of two first-in-class TB drugs, bedaquiline and delamanid, has …

The approval of bedaquiline has placed energy metabolism in the limelight as an attractive
target space for tuberculosis antibiotic development. While bedaquiline inhibits the …

Anthraquinones are polycyclic compounds with an unsaturated diketone structure (quinoid
moiety). As important secondary metabolites of plants, anthraquinones play an important …

The chemical features that impact small-molecule permeability across bacterial membranes
are poorly understood, and the resulting lack of tools to predict permeability presents a …

Many bacteria use large modular enzymes for the synthesis of polyketide and peptide
natural products. These multidomain enzymes contain integrated carrier domains that …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

Dendrobium is the second biggest genus in the Orchidaceae family, some of which have
both ornamental and therapeutic values. Alkaloids are a group of active chemicals found in …

New drugs with new mechanisms of action are urgently required to tackle the global
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …

The compositional and architectural complexity of the mycobacterial cell envelope is
probably the most distinctive feature of the Mycobacterium genus. It is the basis of many of …