Short sleep duration and poor sleep quality are associated with cardiovascular risk, and
sympathetic nervous system (SNS) dysfunction appears to be a key contributor. The present …

Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Abstract Purpose of Review Herein, we summarize recent advances which provide new
insights into the role of the autonomic nervous system in the control of blood flow and blood …

Herein we report in a sample of healthy young men (n= 14) and women (n= 12) that
hyperinsulinemia induces time-dependent decreases in total peripheral resistance and its …

Impaired endothelial insulin signaling and consequent blunting of insulin-induced
vasodilation is a feature of type 2 diabetes (T2D) that contributes to vascular disease and …

Vascular insulin resistance, a major characteristic of obesity and type 2 diabetes (T2D),
manifests with blunting of insulin-induced vasodilation. Although there is evidence that …

Muscle sympathetic nerve activity (MSNA) increases during hyperinsulinemia, primarily
attributed to central nervous system effects. Whether peripheral vasodilation induced by …

Insulin acts centrally to stimulate sympathetic vasoconstrictor outflow to skeletal muscle and
peripherally to promote vasodilation. Given these divergent actions, the “net effect” of insulin …

Context Relative hypoglycemia (RH) is linked to sympathetic responses that can alter
vascular function in individuals with type 2 diabetes. However, less is known about the role …

Insulin has important vasodilatory effects in the peripheral circulation, but less is known
about insulin's role in cerebrovascular control. Herein, we hypothesized both systemic …