Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …

Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …