Sigma-2 receptor plays key roles in promoting tumor cell apoptosis, enhancing efficacy of
anti-tumor drugs, blocking signal transduction controlled by Aβ oligomers, regulating Ca2+ …

The overexpression of σ receptors (σRs) in various types of tumors has prompted a deep
investigation of their role in cancer pathophysiology. Consequently, σR ligands have been …

Simple Summary Triple negative breast cancer (TNBC) is one of the most challenging and
hard to treat breast cancer types due to the lack of the receptor targets that are commonly …

Sigma receptors (σ1 R and σ2 R) are pharmacologically characterized membrane-bound
receptors that bind a wide range of chemical compounds. Alzheimer's disease, traumatic …

Triple-negative breast cancer (TNBC) is one of the most malignant cancers associated with
early metastasis, poor clinical prognosis, and high recurrence rate. TNBC is a distinct …

Abstract The sigma-2 (σ 2) receptor was discovered nearly 40 years ago and was recently
identified as the Transmembrane Protein 97 (TMEM97, also known as MAC30 (Meningioma …

Abstract Sigma-2 receptor (σ 2 R/TMEM97) has been implicated to play important roles in
multiple cellular dysfunctions, such as cell neoplastic proliferation, neuro-inflammation …

Nearly 40 years after the first disclosure of sigma receptors, the sigma-2 (σ2) receptor was
recently identified as the Transmembrane Protein 97 (TMEM97, also known as MAC30 …

Multidrug resistance (MDR) is thought to be one of the main reasons for the failure of
chemotherapy in cancers. ATP-binding cassette subfamily B member 1 (ABCB1) or P …

Abstract Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the
development of antipsychotics. The specific role of each receptor subtype to the …