The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

An animal's nervous system changes as its body grows from birth to adulthood and its
behaviours mature,,,,,,–. The form and extent of circuit remodelling across the connectome is …

Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …

How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain
dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Background It is well established that schizophrenia is associated with structural brain
abnormalities, but whether these are static or progress over time remains controversial …