Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Through harmonized procedures and by sharing site-specific brain metrics (for example,
cortical thickness) or aggregated statistical maps, ENIGMA has set the stage for large-scale …

Background Brain structure abnormalities throughout the course of Parkinson's disease
have yet to be fully elucidated. Objective Using a multicenter approach and harmonized …

Sleep disturbances are common and a major source of disability in Parkinson's disease
(PD). Primary and secondary insomnia, rapid eye movement sleep behavior disorder (RDB) …

Reappraisal of neuropathological studies suggests that pathological hallmarks of
Alzheimer's disease and Parkinson's disease (PD) spread progressively along predictable …

The spreading hypothesis of neurodegeneration assumes an expansion of neural
pathologies along existing neural pathways. Multimodal neuroimaging studies have …

Parkinson's disease varies in severity and age of onset. One source of this variability is sex.
Males are twice as likely as females to develop Parkinson's disease, and tend to have more …