Skeletal infections: microbial pathogenesis, immunity and clinical management
EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …
The effects of type 2 diabetes mellitus on organ metabolism and the immune system
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
B cell activity is impaired in human and mouse obesity and is responsive to an essential fatty acid upon murine influenza infection
R Kosaraju, W Guesdon, MJ Crouch… - The Journal of …, 2017 - journals.aai.org
Obesity is associated with increased risk for infections and poor responses to vaccinations,
which may be due to compromised B cell function. However, there is limited information …
which may be due to compromised B cell function. However, there is limited information …
Modulation of gut microbiota metabolism in obesity-related type 2 diabetes reduces osteomyelitis severity
Staphylococcus aureus is an opportunistic pathogen causing osteomyelitis through
hematogenous seeding or contamination of implants and open wounds following orthopedic …
hematogenous seeding or contamination of implants and open wounds following orthopedic …
B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
K Oleinika, B Slisere, D Catalán… - Clinical and …, 2022 - academic.oup.com
Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver
disease, and cancer. It is also linked with more severe complications from infections …
disease, and cancer. It is also linked with more severe complications from infections …
COVID‐19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advances
M Belchior‐Bezerra, RS Lima, NI Medeiros… - Obesity …, 2022 - Wiley Online Library
In the 2 years since the COVID‐19 pandemic was officially declared, science has made
considerable strides in understanding the disease's pathophysiology, pharmacological …
considerable strides in understanding the disease's pathophysiology, pharmacological …
The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool
MU Sohail, F Mashood, A Oberbach… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus (DM) is a group of metabolic diseases marked by hyperglycemia, which
increases the risk of systemic infections. DM patients are at greater risk of hospitalization …
increases the risk of systemic infections. DM patients are at greater risk of hospitalization …
Hyperglycemia increases severity of Staphylococcus aureus osteomyelitis and influences bacterial genes required for survival in bone
CE Butrico, N Klopfenstein, ER Green… - Infection and …, 2023 - Am Soc Microbiol
Hyperglycemia, or elevated blood glucose, renders individuals more prone to developing
severe Staphylococcus aureus infections. S. aureus is the most common etiological agent of …
severe Staphylococcus aureus infections. S. aureus is the most common etiological agent of …
The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section
Musculoskeletal infections (MSKI), which are a major problem in orthopedics, occur when
the pathogen eludes or overwhelms the host immune system. While effective vaccines and …
the pathogen eludes or overwhelms the host immune system. While effective vaccines and …
The association between body mass index and the risk of hospitalization and mortality due to infection: a prospective cohort study
WS Yang, YC Chang, CH Chang, LC Wu… - Open forum …, 2021 - academic.oup.com
Background We aim to determine whether obesity increases the risk of various infections
using a large prospective population-based cohort. Methods A total of 120 864 adults were …
using a large prospective population-based cohort. Methods A total of 120 864 adults were …