HDV RNA Assays: Performance characteristics, clinical utility and challenges

H Wedemeyer, M Leus, TR Battersby, J Glenn… - Hepatology, 2023 - journals.lww.com
Co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV) results in hepatitis D,
the most severe form of chronic viral hepatitis, frequently leading to liver decompensation …

Multiple regions drive hepatitis delta virus proliferation and are therapeutic targets

J Zi, X Gao, J Du, H Xu, J Niu, X Chi - Frontiers in Microbiology, 2022 - frontiersin.org
Hepatitis Delta Virus (HDV) is the smallest mammalian single-stranded RNA virus. It
requires host cells and hepatitis B virus (HBV) to complete its unique life cycle. The present …

A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β induction

L Suárez-Amarán, C Usai, M Di Scala, C Godoy… - Journal of …, 2017 - Elsevier
Background & Aims Studying hepatitis delta virus (HDV) and developing new treatments is
hampered by the limited availability of small animal models. Herein, a description of a robust …

Novel concepts on mechanisms underlying Hepatitis Delta virus persistence and related pathogenesis

R Salpini, S D'Anna, L Piermatteo… - Journal of Viral …, 2022 - Wiley Online Library
Hepatitis Delta virus is the smallest known human virus, exploiting the HBV surface proteins
(HBsAg) for the release of its progeny and de novo entry into hepatocytes. Ever growing …

Adaptive immune responses, immune escape and immune-mediated pathogenesis during HDV infection

V Oberhardt, M Hofmann, R Thimme… - Viruses, 2022 - mdpi.com
The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm
to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires …

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells

H Karimzadeh, MM Kiraithe, AD Kosinska… - Journal of …, 2018 - Am Soc Microbiol
Virus-specific CD8 T cell response seems to play a significant role in the outcome of
hepatitis delta virus (HDV) infection. However, the HDV-specific T cell epitope repertoire and …

Improved hepatitis delta virus genome characterization by single molecule full‐length genome sequencing combined with VIRiONT pipeline

C Charre, H Regue, P Dény, L Josset… - Journal of Medical …, 2023 - Wiley Online Library
Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection confers a greater risk for
accelerated liver disease progression. Full‐length characterization of HDV genome is …

Variable in vivo hepatitis D Virus (HDV) RNA editing rates according to the HDV genotype

S Dziri, C Rodriguez, A Gerber, S Brichler, C Alloui… - Viruses, 2021 - mdpi.com
Human hepatitis delta virus (HDV) is a small defective RNA satellite virus that requires
hepatitis B virus (HBV) envelope proteins to form its own virions. The HDV genome …

Deep sequencing in the management of hepatitis virus infections

J Quer, F Rodríguez-Frias, J Gregori, D Tabernero… - Virus research, 2017 - Elsevier
The hepatitis viruses represent a major public health problem worldwide. Procedures for
characterization of the genomic composition of their populations, accurate diagnosis …

Inspecting the ribozyme region of hepatitis delta virus genotype 1: conservation and variability

B Pacin-Ruiz, MF Cortese, D Tabernero, S Sopena… - Viruses, 2022 - mdpi.com
The hepatitis delta virus (HDV) genome has an autocatalytic region called the ribozyme,
which is essential for viral replication. The aim of this study was to use next-generation …