The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Objective Development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and the American College of …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Obesity is a complex, multifactorial disease that is strongly associated with multiple
comorbidities. 1–6 These comorbidities include certain types of cancer, cardiovascular …

Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Osteoarthritis (OA) is a leading cause of pain and disability and leads to a reduced quality of
life. The aim was to determine the current evidence on risk factors for onset of knee pain/OA …

Introduction Osteoarthritis (OA) is one of the most common forms of arthritis. There is
accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial …

Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and
progression of disease. Signs of inflammation can be observed in joint fluids and tissues …