Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug
development in cognitive and neuro-degenerative disorders, are allosteric proteins with …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

Allosteric modulation refers to the concept that proteins could exist in multiple
conformational states and that binding of allosteric ligands alters the energy barriers or …

1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …

The divalent cation, zinc is the second most abundant metal in the human body and is
indispensable for life. Zinc concentrations must however, be tightly regulated as deficiencies …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

This review reports on the knowledge about odourant–olfactory receptor interactions and
their projection within the field of structure–odour relationships (SOR). We provide a list of …