Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

The metabolic signature of macrophage responses

A Viola, F Munari, R Sánchez-Rodríguez… - Frontiers in …, 2019 - frontiersin.org
Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

[HTML][HTML] Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

S Willenborg, DE Sanin, A Jais, X Ding, T Ulas… - Cell metabolism, 2021 - cell.com
Wound healing is a coordinated process that initially relies on pro-inflammatory
macrophages, followed by a pro-resolution function of these cells. Changes in cellular …

[HTML][HTML] Metabolism of vascular smooth muscle cells in vascular diseases

J Shi, Y Yang, A Cheng, G Xu… - American Journal of …, 2020 - journals.physiology.org
Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

A guide to immunometabolism for immunologists

LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages

A Batista-Gonzalez, R Vidal, A Criollo… - Frontiers in …, 2020 - frontiersin.org
Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

V Rani, G Deep, RK Singh, K Palle, UCS Yadav - Life sciences, 2016 - Elsevier
Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …

[HTML][HTML] Macrophages and lipid metabolism

A Remmerie, CL Scott - Cellular immunology, 2018 - Elsevier
Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

W Du, L Zhang, A Brett-Morris, B Aguila… - Nature …, 2017 - nature.com
Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-
rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia …