Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
The metabolic signature of macrophage responses
Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …
functions in homeostatic and immune responses. The broad spectrum of macrophage …
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
[HTML][HTML] Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing
Wound healing is a coordinated process that initially relies on pro-inflammatory
macrophages, followed by a pro-resolution function of these cells. Changes in cellular …
macrophages, followed by a pro-resolution function of these cells. Changes in cellular …
[HTML][HTML] Metabolism of vascular smooth muscle cells in vascular diseases
J Shi, Y Yang, A Cheng, G Xu… - American Journal of …, 2020 - journals.physiology.org
Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …
of arteries and are essential for arterial physiology and pathology. It is becoming …
A guide to immunometabolism for immunologists
LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …
New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …
Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …
and cardiovascular complications together constitute metabolic syndrome. The …
[HTML][HTML] Macrophages and lipid metabolism
A Remmerie, CL Scott - Cellular immunology, 2018 - Elsevier
Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
W Du, L Zhang, A Brett-Morris, B Aguila… - Nature …, 2017 - nature.com
Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-
rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia …
rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia …