Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
[HTML][HTML] Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications
Advancements in in silico techniques of lead molecule selection have resulted in the failure
of around 70% of new chemical entities (NCEs). Some of these molecules are getting …
of around 70% of new chemical entities (NCEs). Some of these molecules are getting …
Nanocrystals for controlled delivery: state of the art and approved drug products
Introduction Controlled/extended-release formulations offer numerous benefits over
conventional especially reduced side effects, improved therapeutic outcomes, and high …
conventional especially reduced side effects, improved therapeutic outcomes, and high …
Development of fast dissolving oral films containing lercanidipine HCl nanoparticles in semicrystalline polymeric matrix for enhanced dissolution and ex vivo …
AD Chonkar, JV Rao, RS Managuli, S Mutalik… - European journal of …, 2016 - Elsevier
Lercanidipine is a vasoselective dihydropyridine calcium antagonist, mainly used for the
treatment of hypertension and angina pectoris. However, it suffers from food dependent …
treatment of hypertension and angina pectoris. However, it suffers from food dependent …
Formulation and drying of miconazole and itraconazole nanosuspensions
AM Cerdeira, M Mazzotti, B Gander - International journal of pharmaceutics, 2013 - Elsevier
Miconazole and itraconazole possess adequate membrane permeability, but only slight
water solubility, which limits their bioavailability and antifungal effect. To increase their …
water solubility, which limits their bioavailability and antifungal effect. To increase their …
Development of long-acting injectable suspensions by continuous antisolvent crystallization: An integrated bottom-up process
Our present work elucidated the operational feasibility of direct generation and stabilization
of long-acting injectable (LAI) suspensions of a practically insoluble drug, itraconazole (ITZ) …
of long-acting injectable (LAI) suspensions of a practically insoluble drug, itraconazole (ITZ) …
Novel topical drug delivery systems in acne management: Molecular mechanisms and role of targeted delivery systems for better therapeutic outcomes
P Ghasemiyeh, S Mohammadi-Samani… - Journal of Drug Delivery …, 2022 - Elsevier
Acne vulgaris is a chronic inflammatory skin disorder that involves pilosebaceous units. Due
to the various harmful psychophysical consequences especially in teenagers and younger …
to the various harmful psychophysical consequences especially in teenagers and younger …
Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro–in vivo correlation
TO McDonald, M Giardiello, P Martin… - Advanced …, 2014 - Wiley Online Library
Nanomedicine strategies have produced many commercial products. However, no orally
dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of …
dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of …
Lipid-based nanocarriers as an alternative for oral delivery of poorly water-soluble drugs: peroral and mucosal routes
AC Silva, D Santos, D Ferreira… - Current medicinal …, 2012 - ingentaconnect.com
The hydrophobic character of most drug molecules and their potential for degradation under
the hostile environment of the gastrointestinal tract (GIT) constitutes the main obstacle in the …
the hostile environment of the gastrointestinal tract (GIT) constitutes the main obstacle in the …
Nanocrystal technology for improving therapeutic efficacy of flavonoids
K Gujar, S Wairkar - Phytomedicine, 2020 - Elsevier
Background Bioflavonoids, secondary metabolites of plants, are beneficial in regulating
human physiological mechanisms. Bioflavonoids majorly exist in the dietary intake of fruits …
human physiological mechanisms. Bioflavonoids majorly exist in the dietary intake of fruits …