The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …

Immunology researchers are beginning to explore the possibilities of reproducibility, reuse
and secondary analyses of immunology data. Open-access datasets are being applied in …

The move toward precision medicine has highlighted the importance of understanding
biological variability within and across individuals in the human population. In particular …

Antibody memory protects humans from many diseases. Protective antibody memory
responses require activation of transcriptional programs, cell proliferation, and production of …

A major goal of systems biology is the development of models that accurately predict
responses to perturbation. Constructing such models requires the collection of dense …

The elderly have reduced humoral immunity, as manifested by increased susceptibility to
infections and impaired vaccine responses. To investigate the effects of aging on B-cell …

Wide heterogeneity of disease course ranging from asymptomatic spread, to respiratory
failure and death, has become a hallmark of the SARS-CoV-2 (COVID-19) pandemic. While …

Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in
response to vaccination, producing long-lived antibody secreting plasma cells and memory …

Generating a diverse B cell immunoglobulin repertoire is essential for protection against
infection. The repertoire in humans can now be comprehensively measured by high …

Nearly all licensed vaccines have been developed to confer protection against infectious
diseases by stimulating the production of antibodies by B cells, but the nature of a successful …