Targeting CSF1R in myeloid-derived suppressor cells: insights into its immunomodulatory functions in colorectal cancer and therapeutic implications
X Tong, S Qiao, Z Dong, X Zhao, X Du… - Journal of …, 2024 - Springer
Objective This study aimed to investigate the critical role of MDSCs in CRC immune
suppression, focusing on the CSF1R and JAK/STAT3 signaling axis. Additionally, it …
suppression, focusing on the CSF1R and JAK/STAT3 signaling axis. Additionally, it …
Delivery of miR-15b-5p via magnetic nanoparticle-enhanced bone marrow mesenchymal stem cell-derived extracellular vesicles mitigates diabetic osteoporosis by …
C Xu, Z Wang, Y Liu, K Duan, J Guan - Cell Biology and Toxicology, 2024 - Springer
Diabetic osteoporosis (DO) presents significant clinical challenges. This study aimed to
investigate the potential of magnetic nanoparticle-enhanced extracellular vesicles (GMNPE …
investigate the potential of magnetic nanoparticle-enhanced extracellular vesicles (GMNPE …
Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia‐reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1 …
L Zhao, Y Chen, H Li, X Ding, J Li - CNS Neuroscience & …, 2024 - Wiley Online Library
Introduction Cerebral ischemia‐reperfusion injury (CIRI) is a common and debilitating
complication of cerebrovascular diseases such as stroke, characterized by mitochondrial …
complication of cerebrovascular diseases such as stroke, characterized by mitochondrial …
[HTML][HTML] Kidney fibrosis molecular mechanisms Spp1 influences fibroblast activity through transforming growth factor beta smad signaling
H Ding, Z Xu, Y Lu, Q Yuan, J Li, Q Sun - Iscience, 2024 - cell.com
Kidney fibrosis marks a critical phase in chronic kidney disease with its molecular intricacies
yet to be fully understood. This study's deep dive into single-cell sequencing data of renal …
yet to be fully understood. This study's deep dive into single-cell sequencing data of renal …
New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration
L Lu, L Wang, M Yang, H Wang - Molecular Medicine, 2024 - Springer
This study investigates the potential molecular mechanisms by which O-GlcNAc modification
of YTHDF2 regulates the cell cycle and participates in intervertebral disc degeneration …
of YTHDF2 regulates the cell cycle and participates in intervertebral disc degeneration …
Ascl1 is involved in the pathogenesis of schizophrenia by regulation of genes related to cell proliferation, neuronal signature formation, and neuroplasticity
DA Abashkin, DS Karpov, AO Kurishev… - International Journal of …, 2023 - mdpi.com
Schizophrenia (SZ) is a common psychiatric neurodevelopmental disorder with a complex
genetic architecture. Genome-wide association studies indicate the involvement of several …
genetic architecture. Genome-wide association studies indicate the involvement of several …
[HTML][HTML] Transcriptional regulation of DLGAP5 by AR suppresses p53 signaling and inhibits CD8+ T cell infiltration in triple-negative breast cancer
Q Pan, D Ma, Y Xiao, K Ji, J Wu - Translational Oncology, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is a challenging subtype with unclear biological
mechanisms. Recently, the transcription factor androgen receptor (AR) and its regulation of …
mechanisms. Recently, the transcription factor androgen receptor (AR) and its regulation of …
Targeting Nrf2/PHKG2 axis to enhance radiosensitivity in NSCLC
F Han, S Chen, K Zhang, K Zhang, M Wang… - NPJ Precision …, 2024 - nature.com
While ferroptosis shows promise in anti-cancer strategy, the molecular mechanisms behind
this process remain poorly understood. Our research aims to highlight the regulation of …
this process remain poorly understood. Our research aims to highlight the regulation of …
High-altitude hypoxia promotes BRD4-mediated activation of the Wnt/β-catenin pathway and disruption of intestinal barrier
YH Yang, F Yan, W Yuan, PS Shi, SM Wu, DJ Cui - Cellular Signalling, 2024 - Elsevier
Hypobaric hypoxia, commonly experienced at elevated altitudes, presents significant
physiological challenges. Our investigation is centered on the impact of the bromodomain …
physiological challenges. Our investigation is centered on the impact of the bromodomain …
Curcumin nanoparticles in heat stroke management
F Guo, Y Wu, J Liu - Journal of Nanobiotechnology, 2024 - Springer
Objective The exacerbation of extreme high-temperature events due to global climate
change poses a significant challenge to public health, particularly impacting the central …
change poses a significant challenge to public health, particularly impacting the central …