Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Premature ovarian insufficiency (POI) is the cessation of menstruation before the age of 40
and can result from different etiologies, including genetic, autoimmune, and iatrogenic. Of …

Summary Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …

Primary ovarian insufficiency (POI) is characterized by amenorrhea, increased follicle-
stimulating hormone (FSH) levels, and hypoestrogenism, leading to infertility before the age …

Primary ovarian insufficiency (POI) is a heterogeneous disorder associated with several
genes. The majority of cases are still unsolved. Our aim was to identify the molecular …

As a species without master sex-determining genes, zebrafish displays high plasticity in sex
differentiation, making it an excellent model for studying the regulatory mechanisms …

OBJECTIVES: High-throughput sequencing of genomes, exomes, and disease-focused
gene panels is becoming increasingly common for molecular diagnostics. However …

Context Primary ovarian insufficiency (POI) is a cause of female infertility. However, the
genetic etiology of this disorder remains unknown in most patients with POI. Objective To …

Background To dissect the genetic alteration in two sisters with premature ovarian
insufficiency (POI) from a consanguineous family. Methods Whole-exome sequencing …

Disorders of sex development (DSDs) comprise a spectrum of disorders in which
chromosomal, genetic, gonadal, hormonal, or anatomic aspects of sex are atypical …