Serpins are a superfamily of proteins characterized by their common function as serine
protease inhibitors. So far, 36 serpins from nine clades have been identified. These proteins …

The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to
optimize allocation of treatment and resources in intensive care, as clinically established risk …

Objective Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease with a complex
etiology that lacks biomarkers predicting disease progression. The objective of this study …

Background: Serine proteinase inhibitor A3 (SERPINA3) has been discovered in the
pathogenesis of many human diseases, but little is known about the role of SERPINA3 in …

Background Angiogenesis is an important parameter in the development of diabetic
retinopathy (DR), and it is indicative of an early stage evolving into a late phase. Therefore …

Vascular aging is defined as organic and functional changes in blood vessels, in which
decline in autophagy levels, DNA damage, MicroRNA (miRNA), oxidative stress, sirtuin, and …

Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like
molecule, shares many of the interactive properties of HS. The aim of this review was to …

Acute kidney injury (AKI) occurs in half of patients with septic shock, resulting in
unacceptably high mortality. However, effective preventive treatments are still lacking. We …

The purpose of study was to evaluate that kallistatin deficiency causes excessive production
of reactive oxygen species and exacerbates neuronal injury after cardiac arrest. For in vitro …