SHERLOCK and DETECTR: CRISPR-Cas systems as potential rapid diagnostic tools for emerging infectious diseases

MI Mustafa, AM Makhawi - Journal of Clinical Microbiology, 2021 - Am Soc Microbiol
Infectious diseases are one of the most intimidating threats to human race, responsible for
an immense burden of disabilities and deaths. Rapid diagnosis and treatment of infectious …

CRISPR systems for COVID-19 diagnosis

H Rahimi, M Salehiabar, M Barsbay, M Ghaffarlou… - ACS …, 2021 - ACS Publications
The emergence of the new coronavirus 2019 (COVID-19) was first seen in December 2019,
which has spread rapidly and become a global pandemic. The number of cases of COVID …

CRISPR based therapeutics: a new paradigm in cancer precision medicine

S Das, S Bano, P Kapse, GC Kundu - Molecular Cancer, 2022 - Springer
Background Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-
associated protein (Cas) systems are the latest addition to the plethora of gene-editing tools …

Microfluidic-based technologies for diagnosis, prevention, and treatment of COVID-19: recent advances and future directions

EA Tarim, M Anil Inevi, I Ozkan, S Kecili, E Bilgi… - Biomedical …, 2023 - Springer
The COVID-19 pandemic has posed significant challenges to existing healthcare systems
around the world. The urgent need for the development of diagnostic and therapeutic …

[HTML][HTML] A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to 177Lutetium-DOTA-octreotate radionuclide therapy

K Waldeck, J Van Zuylekom, C Cullinane, T Gulati… - Theranostics, 2023 - ncbi.nlm.nih.gov
Peptide receptor radionuclide therapy (PRRT) using 177 Lutetium-DOTA-octreotate (LuTate)
for neuroendocrine tumours (NET) is now an approved treatment available in many …

[HTML][HTML] Advancements in CRISPR screens for the development of cancer immunotherapy strategies

YR Li, Z Lyu, Y Tian, Y Fang, Y Zhu, Y Chen… - Molecular Therapy …, 2023 - cell.com
CRISPR screen technology enables systematic and scalable interrogation of gene function
by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer …

The rise and future of CRISPR-based approaches for high-throughput genomics

S Vercauteren, S Fiesack, L Maroc… - FEMS microbiology …, 2024 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR) has revolutionized the
field of genome editing. To circumvent the permanent modifications made by traditional …

CRISPR-Cas12a test strip (CRISPR/CAST) package: In-situ detection of Brucella from infected livestock

S Dang, H Sui, S Zhang, D Wu, Z Chen, J Zhai… - BMC Veterinary …, 2023 - Springer
Background Brucellosis is a common zoonotic disease caused by Brucella, which causes
enormous economic losses and public burden to epidemic areas. Early and precise …

CRISPR innovations in tissue engineering and gene editing

ZS Razavi, M Soltani, M Souri, AJ van Wijnen - Life Sciences, 2024 - Elsevier
The CRISPR/Cas9 system is a powerful tool for genome editing, utilizing the Cas9 nuclease
and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be …

CRISPR-Cas Systems in the Fight Against Antimicrobial Resistance: Current Status, Potentials, and Future Directions

MM Ahmed, HH Kayode, OJ Okesanya… - Infection and Drug …, 2024 - Taylor & Francis
Background Antimicrobial resistance (AMR) is a critical global health concern that threatens
the efficacy of existing antibiotics and poses significant challenges to public health and the …