Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Cancers have the ability to develop resistance to traditional therapies, and the increasing
prevalence of these drug resistant cancers necessitates further research and treatment …

Abstract The green Se NPs (selenium nanoparticles) are formed by simple mixing of
Withania somnifera (W. somnifera) leaves extract and selenious acid (H 2 SeO 3) solution …

Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …

The platinum analogues, cisplatin and carboplatin, are among the most widely used
chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity …

DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its
derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …