[HTML][HTML] Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

[HTML][HTML] The potential role of gut microbiota in Alzheimer's disease: from diagnosis to treatment

A Varesi, E Pierella, M Romeo, GB Piccini, C Alfano… - Nutrients, 2022 - mdpi.com
Gut microbiota is emerging as a key regulator of many disease conditions and its
dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal …

Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

[HTML][HTML] Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

[HTML][HTML] Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

J Chu, S Feng, C Guo, B Xue, K He, L Li - Biomedicine & …, 2023 - Elsevier
The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

[HTML][HTML] Overlapping mechanisms of action of brain-active bacteria and bacterial metabolites in the pathogenesis of common brain diseases

TP Eicher, MH Mohajeri - Nutrients, 2022 - mdpi.com
The involvement of the gut microbiota and the metabolites of colon-residing bacteria in brain
disease pathogenesis has been covered in a growing number of studies, but comparative …

Gut-derived β-amyloid: Likely a centerpiece of the gut–brain axis contributing to Alzheimer's pathogenesis

J Jin, Z Xu, L Zhang, C Zhang, X Zhao, Y Mao… - Gut …, 2023 - Taylor & Francis
Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …

[HTML][HTML] Crosstalk between gut and brain in Alzheimer's disease: the role of gut microbiota modulation strategies

U Shabbir, MS Arshad, A Sameen, DH Oh - Nutrients, 2021 - mdpi.com
The gut microbiota (GM) represents a diverse and dynamic population of microorganisms
and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies …

[HTML][HTML] The role of microbiome in brain development and neurodegenerative diseases

V Nandwana, NK Nandwana, Y Das, M Saito, T Panda… - Molecules, 2022 - mdpi.com
Hundreds of billions of commensal microorganisms live in and on our bodies, most of which
colonize the gut shortly after birth and stay there for the rest of our lives. In animal models …