Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Complex carbohydrates are ubiquitous in nature, and together with proteins and nucleic
acids they comprise the building blocks of life. But unlike proteins and nucleic acids …

The primary sequence of a biopolymer encodes the essential information for folding,
permitting to carry out sophisticated functions. Inspired by natural biopolymers, peptide and …

We provide evidence for CH-based nonconventional hydrogen bonds (H-bonds) for 10
Lewis antigens and two of their rhamnose analogues. We also characterize the …

Highlights•Cells are covered by a dense, protective glycan layer, the glycocalyx.•Viruses,
bacteria and fungi exploit these glycans to gain entry to the host.•The mucus layer covering …

Complex carbohydrates (glycans) are the most abundant and versatile biopolymers in
nature. The broad diversity of biochemical functions that carbohydrates cover is a direct …

Ligand conformational entropy plays an important role in carbohydrate recognition events.
Glycans are characterized by intrinsic flexibility around the glycosidic linkages, thus in most …

The conformational flexibility of the glycosaminoglycans (GAGs) is known to be key in their
binding and biological function, for example in regulating coagulation and cell growth. In this …

Cholera is caused by Vibrio cholerae and is an example of a blood-group-dependent
disease. Recent studies suggest that the receptor-binding B subunit of the cholera toxin (CT) …

Fc glycosylation of human immunoglobulins G (IgGs) is essential for their structural integrity
and activity. Interestingly, the specific nature of the Fc glycoforms is known to modulate the …