The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Phenolic phytochemicals are thought to promote optimal health, partly via their antioxidant
effects in protecting cellular components against free radicals. The aims of this study were to …

Reactive astrocytes frequently surround degenerating motor neurons in patients and
transgenic animal models of amyotrophic lateral sclerosis (ALS). We report here that …

The rate constant for the reaction of nitric oxide with superoxide virtually assures that
peroxynitrite will be formed to some extent in any cell or tissue where both radicals exist …

Oxidative stress mediated by nitric oxide (NO) and its toxic metabolite peroxynitrite has
previously been associated with motor neuron degeneration in amyotrophic lateral sclerosis …

Mammalian cells are equipped with elaborate systems for protection against the toxicity of
reactive oxygen and nitrogen species and electrophiles that are constant dangers to the …

To elucidate potential mechanisms of S-nitrosothiol formation in vivo, we studied nitrosation
of GSH and albumin by nitric oxide (• NO), peroxynitrite, and• NO/O2•−. In the presence of …

In 32D cl 3 hematopoietic progenitor cells, the overexpression of manganese superoxide
dismutase (MnSOD, SOD2), the enzyme normally found in mitochondria, protects against …

diaminofluorescein diacetate (DAF‐2DA) is widely used as a fluorescent probe to detect
endogenously produced nitric oxide (NO). Recent reports that refer to the high sensitivity of …

Background: Overproduction of nitric oxide (NO) has been recognized as a major
mechanism of neurotoxicity. NO reacts with superoxide to generate peroxynitrite, a strong …