Muscarinic signaling affects attention, action selection, learning, and memory through
multiple signaling cascades, which act at different timescales and which alter ion channels …

Highlights•Cholinergic actions with specific spatiotemporal patterns regulate cognition.•Both
nicotinic and muscarinic responses can be fast and precise.•Interneuron-specific cholinergic …

ACh release into the rodent prefrontal cortex is predictive of successful performance of cue
detection tasks, yet the cellular mechanisms underlying cholinergic modulation of cortical …

Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here
we show that transient muscarinic acetylcholine receptor activation directly inhibits …

Objectives: A common experimental model of status epilepticus (SE) utilizes intraperitoneal
administration of the cholinergic agonist pilocarpine preceded by methyl‐scopolamine …

The entorhinal cortex–hippocampus complex is believed to be the site of origin of seizure
activity in the majority of patients with temporal lobe epilepsy (TLE). Both these regions are …

The cholinergic system is crucially involved in several cognitive processes including
attention, learning and memory. Muscarinic actions have profound effects on the intrinsic …

Early coordinated network activity promotes the development of cortical structures. Although
these early activity patterns have been recently characterized with respect to their …

DQAsomes (dequalinium-based liposome-like vesicles) are the prototype for all
mitochondria-targeted vesicular pharmaceutical nanocarrier systems. First described in …

Key points Phasic activation of M1 muscarinic receptors generates transient inhibition
followed by longer lasting excitation in neocortical pyramidal neurons. Corticopontine …