The first total synthesis of the pentacyclic phenylnaphthacenoid type II polyketide antibiotic
formicamycin H is described. A key feature of the synthesis involves the convergent …

Type II polyketide synthase (PKS) systems are a rich source of structurally diverse polycyclic
aromatic compounds with clinically relevant antibiotic and chemotherapeutic properties. The …

Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6+
6+ 6+ 6]+[5+ 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 Δ …

Synthetic biology is a science that uses engineering principles to design and build new
biological systems. Researchers in this field are harnessing the power of “biology” to solve …

In our continued desire to isolate more bioactive compounds from the Streptomyces sp.
MA37 variant, ΔaccJ, three new accramycin derivatives have been successfully …