Filamentous fungi are able to produce a wide range of valuable proteins and enzymes for
many industrial applications. Recent advances in fungal genomics and experimental …

The filamentous fungus Aspergillus oryzae is an important strain in the traditional
fermentation and food processing industries and is often used in the production of soy …

Sesquiterpenes are important materials in pharmaceuticals and industry. Metabolic
engineering has been successfully used to produce these valuable compounds in microbial …

DNA vaccination has been of great interest since its discovery in the 1990s due to its ability
to elicit both humoral and cellular immune responses. DNA vaccines consist of a DNA …

Aspergilli have been widely used in the production of organic acids, enzymes, and
secondary metabolites for almost a century. Today, several GRAS (generally recognized as …

Terpenoids and polyphenols are high-valued plant secondary metabolites. Their high
antimicrobial activities demonstrate their huge potential as natural preservatives in the food …

High throughput genome sequencing has revealed a multitude of potential secondary
metabolites biosynthetic pathways that remain cryptic. Pathway reconstruction coupled with …

Codon usage biases are found in all genomes and influence protein expression levels. The
codon usage effect on protein expression was thought to be mainly due to its impact on …

Filamentous fungi are critical to production of many commercial enzymes and organic
compounds. Fungal-based systems have several advantages over bacterial-based systems …

Despite considerable efforts, no physical mechanism has been shown to explain N-terminal
codon bias in prokaryotic genomes. Using a systematic study of synonymous substitutions in …