The effect of hypoxia and hypoxia-associated pathways in the regulation of antitumor response: friends or foes?
R Abou Khouzam, RF Zaarour… - Frontiers in …, 2022 - frontiersin.org
Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …
Benchmarking of cell type deconvolution pipelines for transcriptomics data
F Avila Cobos, J Alquicira-Hernandez… - Nature …, 2020 - nature.com
Many computational methods have been developed to infer cell type proportions from bulk
transcriptomics data. However, an evaluation of the impact of data transformation, pre …
transcriptomics data. However, an evaluation of the impact of data transformation, pre …
RNA-Seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types
The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …
strategies to understand and treat diseases. We characterized 29 immune cell types within …
Human germinal centres engage memory and naive B cells after influenza vaccination
Influenza viruses remain a major public health threat. Seasonal influenza vaccination in
humans primarily stimulates pre-existing memory B cells, which differentiate into a transient …
humans primarily stimulates pre-existing memory B cells, which differentiate into a transient …
An immune-cell signature of bacterial sepsis
Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …
A benchmark for RNA-seq deconvolution analysis under dynamic testing environments
Background Deconvolution analyses have been widely used to track compositional
alterations of cell types in gene expression data. Although a large number of novel methods …
alterations of cell types in gene expression data. Although a large number of novel methods …
SCDC: bulk gene expression deconvolution by multiple single-cell RNA sequencing references
Recent advances in single-cell RNA sequencing (scRNA-seq) enable characterization of
transcriptomic profiles with single-cell resolution and circumvent averaging artifacts …
transcriptomic profiles with single-cell resolution and circumvent averaging artifacts …
Beyond experiments
It is often claimed that only experiments can support strong causal inferences and therefore
they should be privileged in the behavioral sciences. We disagree. Overvaluing experiments …
they should be privileged in the behavioral sciences. We disagree. Overvaluing experiments …
[HTML][HTML] A potently neutralizing antibody protects mice against SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions
of infections and hundreds of thousands of deaths globally. There are no widely available …
of infections and hundreds of thousands of deaths globally. There are no widely available …
Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study
Background There is an urgent need for biomarkers to better stratify patients with idiopathic
pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical …
pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical …