The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

IL6 is a pleiotropic cytokine that is made in response to perturbations in homeostasis. IL6
becomes elevated in the acute response to host injury and can activate immune cells, direct …

The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …

Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now
known to be a multifunctional cytokine that regulates the immune response, hematopoiesis …

Appropriate control of leukocyte recruitment and activation is a fundamental requirement for
competent host defense and resolving inflammation. A pivotal event that defines the …

Positive and negative costimulation by members of the CD28 family is critical for the
development of productive immune responses against foreign pathogens and their proper …

Cytokine receptors, which exist in membrane-bound and soluble forms, bind their ligands
with comparable affinity. Although most soluble receptors are antagonists and compete with …

The paradigm that emerged from studies during the past decade established a central role
for Jak–Stat (signal transducer and activator of transcription) signaling pathways in …

Abstract Interleukin 6 (IL-6) is a cytokine produced by immune and nonimmune cells and
exhibits functional pleiotropy and redundancy. IL-6 plays an important role in the …

IL-6 is a pleiotropic cytokine involved in many biological functions that affect tissues beyond
the immune system and the vasculature. This multifunctional cytokine exerts its actions via …