In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a
necessary step prior to in vivo testing. A MCL that accurately represents the physiology of …

Cardiovascular disease is the leading cause of mortality in the US and in westernized
countries with ischemic heart disease accounting for the majority of these deaths …

Artificial blood pumps are today's most promising bridge‐to‐recovery (BTR), bridge‐to‐
transplant (BTT), and destination therapy solutions for patients suffering from intractable …

Vascular disease is the leading cause of morbidity and mortality and a major cause of
disability for Americans, and arterial stenosis is its most common form in systemic arteries …

Controlled and repeatable in vitro evaluation of cardiovascular devices using a mock
circulation loop (MCL) is essential prior to in vivo or clinical trials. MCLs often consist of only …

In this paper, a state-space model is developed through theoretical analysis and numerical
solutions to approximate the response of the human circulatory system. This system model …

Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo
trials; however they lack the vital autoregulatory responses that occur in humans. This study …

Mock circulatory loops (MCLs) are usually developed for assessment of ventricular assist
devices and consist of abstracted anatomical structures represented by connecting tubing …

Purpose Computational models of cardiovascular structures rely on their accurate
mechanical characterization. A validated method able to infer the material properties of …

A mock circulation system has been developed to approximate key anatomic features and
simulate the pressures and flows of an infant. Pulsatile flow is generated by 10 cc pulsatile …