A review on coronary artery disease, its risk factors, and therapeutics

AK Malakar, D Choudhury, B Halder… - Journal of cellular …, 2019 - Wiley Online Library
Coronary artery disease (CAD) is one of the major cardiovascular diseases affecting the
global human population. This disease has been proved to be the major cause of death in …

Ferroptosis and its emerging roles in cardiovascular diseases

N Li, W Jiang, W Wang, R Xiong, X Wu… - Pharmacological Research, 2021 - Elsevier
Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

DB Kell, E Pretorius - Metallomics, 2014 - academic.oup.com
Abstract" Serum ferritin" presents a paradox, as the iron storage protein ferritin is not
synthesised in serum yet is to be found there. Serum ferritin is also a well known …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …

DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Ferritin self-assembly, structure, function, and biotechnological applications

VV Sudarev, SM Dolotova, SM Bukhalovich… - International journal of …, 2023 - Elsevier
Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It
plays a crucial role in various metabolic pathways, inflammation processes, stress response …

Pathological roles of iron in cardiovascular disease

M Kobayashi, T Suhara, Y Baba… - Current drug …, 2018 - ingentaconnect.com
Iron is an essential mineral required for a variety of vital biological functions. Despite being
vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factor …

Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes

JP McRedmond, SD Park, DF Reilly… - Molecular & Cellular …, 2004 - ASBMB
Platelets, while anucleate, contain RNA, some of which is translated into protein upon
activation. Hypothesising that the platelet proteome is reflected in the transcriptome, we …

Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from coronary artery disease

X Wu, K Qin, CD Iroegbu, K Xiang… - Journal of Cellular …, 2022 - Wiley Online Library
Ferroptosis plays a key role in the death of cells including cardiomyocytes, and it is related to
a variety of cardiac diseases. However, the role of ferroptosis‐related genes (FRGs) in …

Urinary proteomic biomarkers in coronary artery disease

LU Zimmerli, E Schiffer, P Zürbig, DM Good… - Molecular & cellular …, 2008 - ASBMB
Urinary proteomics is emerging as a powerful non-invasive tool for diagnosis and monitoring
of variety of human diseases. We tested whether signatures of urinary polypeptides can …