[HTML][HTML] Pharmacogenomics of hypertension treatment
J Rysz, B Franczyk, M Rysz-Górzyńska… - International journal of …, 2020 - mdpi.com
Hypertension is one of the strongest modifiable cardiovascular risk factors, affecting an
increasing number of people worldwide. Apart from poor medication adherence, the low …
increasing number of people worldwide. Apart from poor medication adherence, the low …
[HTML][HTML] Antihypertensives associated adverse events: a review of mechanisms and pharmacogenomic biomarkers available evidence in multi-ethnic populations
Hypertension remains a significant health burden worldwide, re-emphasizing the
outstanding need for more effective and safer antihypertensive therapeutic approaches …
outstanding need for more effective and safer antihypertensive therapeutic approaches …
[HTML][HTML] Genetic variants for personalised management of very low carbohydrate ketogenic diets
The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet proven to be
effective for the reversal of obesity, metabolic syndrome and type 2 diabetes, and holding …
effective for the reversal of obesity, metabolic syndrome and type 2 diabetes, and holding …
[HTML][HTML] Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review
Blood pressure (BP) is a complex trait that is regulated by multiple physiological pathways
and include but is not limited to extracellular fluid volume homeostasis, cardiac contractility …
and include but is not limited to extracellular fluid volume homeostasis, cardiac contractility …
[HTML][HTML] Influence of genetic west African ancestry on metabolomics among hypertensive patients
Patients with higher genetic West African ancestry (GWAA) have hypertension (HTN) that is
more difficult to treat and have higher rates of cardiovascular diseases (CVD) and differential …
more difficult to treat and have higher rates of cardiovascular diseases (CVD) and differential …
[HTML][HTML] Dapagliflozin mediates Plin5/PPARα signaling axis to attenuate cardiac hypertrophy
J Yu, H Zhao, X Qi, L Wei, Z Li, C Li, X Zhang… - Frontiers in …, 2021 - frontiersin.org
Objective: The purpose of this study was to investigate the effect of dapagliflozin (DAPA), a
sodium-glucose cotransporter 2 inhibitor, on relieving cardiac hypertrophy and its potential …
sodium-glucose cotransporter 2 inhibitor, on relieving cardiac hypertrophy and its potential …
Genomic association analysis reveals variants associated with blood pressure response to beta‐blockers in European Americans
European Americans (EA) have a better antihypertensive response to β‐blockers when
compared with African Americans, albeit with some variability. We undertook a genomewide …
compared with African Americans, albeit with some variability. We undertook a genomewide …
[HTML][HTML] Exploration of CYP21A2 and CYP17A1 polymorphisms and preeclampsia risk among Chinese Han population: a large-scale case-control study based on …
B Hou, X Jia, Z Deng, X Liu, H Liu, H Yu, S Liu - Human Genomics, 2020 - Springer
Background Several genome-wide association studies have identified single-nucleotide
polymorphisms (SNPs), such as rs4409766, rs1004467, and rs3824755 in CYP17A1 and …
polymorphisms (SNPs), such as rs4409766, rs1004467, and rs3824755 in CYP17A1 and …
[HTML][HTML] Genetic contributors of efficacy and adverse metabolic effects of chlorthalidone in African Americans from the genetics of hypertension associated treatments …
Hypertension is a leading risk factor for cardiovascular disease mortality. African Americans
(AAs) have the highest prevalence of hypertension in the United States, and to alleviate the …
(AAs) have the highest prevalence of hypertension in the United States, and to alleviate the …
[HTML][HTML] Genome wide analysis approach suggests chromosome 2 locus to be associated with thiazide and thiazide like-diuretics blood pressure response
Chlorthalidone (CTD) is more potent than hydrochlorothiazide (HCTZ) in reducing blood
pressure (BP) in hypertensive patients, though both are plagued with BP response …
pressure (BP) in hypertensive patients, though both are plagued with BP response …