Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the
signal transduction and cooperative properties of bacterial regulatory enzymes and …

Exactly 50 years ago, biochemists raised the question of the mechanism of the
conformational change that mediates “allosteric” interactions between regulatory sites and …

Hemoglobin (Hb) is a truly remarkable molecule. Human adult hemoglobin (Hb A) has a
tetrameric structure consisting of two α-chains with 141 amino acids each and two β-chains …

Highlights•Time-resolved structural information is key to understanding biological
mechanism.•The molecular details of biomolecular catalysis and regulation can be studied …

Controlling the activity of proteins with azobenzene photoswitches is a potent tool for
manipulating their biological function. With the help of light, it is possible to change binding …

The concept of indirect or'allosteric'interaction between topographically distinct sites, and the
subsequent 1965 Monod-Wyman-Changeux (MWC) model for the conformational change …

Two competing and mutually exclusive mechanisms of ligand recognition–conformational
selection and induced fit–have dominated our interpretation of ligand binding in biological …

The increasingly narrow and brilliant beams at X-ray facilities reduce the requirements for
both sample volume and data acquisition time. This creates new possibilities for the types …

The 50th anniversary of the classic Monod–Wyman–Changeux (MWC) model provides an
opportunity to survey the broader conceptual and quantitative implications of this …