p300 and CREB-binding protein (CBP), two homologous lysine acetyltransferases in
metazoans, have a myriad of cellular functions. They exert their influence mainly through …

Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …

With hundreds of epigenomic maps, the opportunity arises to exploit the correlated nature of
epigenetic signals, across both marks and samples, for large-scale prediction of additional …

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability,
metabolism and ageing,. SIRT7 is a mammalian sirtuin whose biochemical activity …

Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …

Allostery is an intrinsic property of many globular proteins and enzymes that is
indispensable for cellular regulatory and feedback mechanisms. Recent theoretical and …

Post-translational histone modifications are known to be altered in cancer cells, and loss of
selected histone acetylation and methylation marks has recently been shown to predict …

Cancer cells exhibit alterations in histone modification patterns at individual genes and
globally at the level of single nuclei in individual cells. We demonstrated previously that …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

MicroRNAs are small, non-coding RNAs that negatively regulate gene expression. It has
been proposed that microRNAs could function in the regulation of innate immunity,, but this …