Exploitation of EP300 and CREBBP lysine acetyltransferases by cancer
N Attar, SK Kurdistani - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
p300 and CREB-binding protein (CBP), two homologous lysine acetyltransferases in
metazoans, have a myriad of cellular functions. They exert their influence mainly through …
metazoans, have a myriad of cellular functions. They exert their influence mainly through …
How viruses hijack cell regulation
Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …
relationship with their host, and as such, their genomes have been shaped directly by …
[HTML][HTML] Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues
With hundreds of epigenomic maps, the opportunity arises to exploit the correlated nature of
epigenetic signals, across both marks and samples, for large-scale prediction of additional …
epigenetic signals, across both marks and samples, for large-scale prediction of additional …
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
MF Barber, E Michishita-Kioi, Y Xi, L Tasselli, M Kioi… - Nature, 2012 - nature.com
Sirtuin proteins regulate diverse cellular pathways that influence genomic stability,
metabolism and ageing,. SIRT7 is a mammalian sirtuin whose biochemical activity …
metabolism and ageing,. SIRT7 is a mammalian sirtuin whose biochemical activity …
Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation
Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …
Modulation of allostery by protein intrinsic disorder
Allostery is an intrinsic property of many globular proteins and enzymes that is
indispensable for cellular regulatory and feedback mechanisms. Recent theoretical and …
indispensable for cellular regulatory and feedback mechanisms. Recent theoretical and …
Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome
SE Elsheikh, AR Green, EA Rakha, DG Powe… - Cancer research, 2009 - AACR
Post-translational histone modifications are known to be altered in cancer cells, and loss of
selected histone acetylation and methylation marks has recently been shown to predict …
selected histone acetylation and methylation marks has recently been shown to predict …
Global levels of histone modifications predict prognosis in different cancers
DB Seligson, S Horvath, MA McBrian, V Mah… - The American journal of …, 2009 - Elsevier
Cancer cells exhibit alterations in histone modification patterns at individual genes and
globally at the level of single nuclei in individual cells. We demonstrated previously that …
globally at the level of single nuclei in individual cells. We demonstrated previously that …
Epigenetics in cancer: targeting chromatin modifications
Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …
altered gene expression and changes in cell behavior. Aberrant gene expression and …
miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator
D Lagos, G Pollara, S Henderson, F Gratrix… - Nature cell …, 2010 - nature.com
MicroRNAs are small, non-coding RNAs that negatively regulate gene expression. It has
been proposed that microRNAs could function in the regulation of innate immunity,, but this …
been proposed that microRNAs could function in the regulation of innate immunity,, but this …