Paracoccidioidomycosis: current status and future trends

RC Hahn, F Hagen, RP Mendes, E Burger… - Clinical microbiology …, 2022 - Am Soc Microbiol
Paracoccidioidomycosis (PCM), initially reported in 1908 in the city of São Paulo, Brazil, by
Adolpho Lutz, is primarily a systemic and neglected tropical mycosis that may affect …

The pathobiology of Paracoccidioides brasiliensis

MI Borges-Walmsley, D Chen, X Shu… - Trends in microbiology, 2002 - cell.com
Paracoccidioides brasiliensis causes one of the most prevalent systemic mycoses in Latin
America–paracoccidioidomycosis. It is a dimorphic fungus that undergoes a complex …

An overview of the immunopathology of human paracoccidioidomycosis

G Benard - Mycopathologia, 2008 - Springer
We review here the advances in the understanding of the immunopathology of human
paracoccidioidomycosis (PCM). Its investigation must take in account the intriguing natural …

Imbalance of IL-2, IFN-γ and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis

G Benard, CC Romano, CR Cacere, M Juvenale… - Cytokine, 2001 - Elsevier
Patients with paracoccidioidomycosis (PCM) display a certain degree of
immunecompromise characterized by lymphocyte hyporesponsiveness to the main …

Interferon-γ and tumor necrosis factor-α determine resistance to Paracoccidioides brasiliensis infection in mice

JT Souto, F Figueiredo, A Furlanetto, K Pfeffer… - The American journal of …, 2000 - Elsevier
To investigate the role of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) in the
resistance to Paracoccidioides brasiliensis (Pb) infection, mice with homologous disruption …

[HTML][HTML] Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls

SJ Oliveira, RL Mamoni, CC Musatti… - Microbes and …, 2002 - Elsevier
Cellular immune response to Paracoccidiodes brasiliensis antigens (PbAg) was evaluated
in patients with the juvenile (JF) and adult (AF) forms of paracoccidioidomycosis as well as …

A Parasitic Phase-Specific Adhesin of Coccidioides immitis Contributes to the Virulence of This Respiratory Fungal Pathogen

CY Hung, JJ Yu, KR Seshan, U Reichard… - Infection and …, 2002 - Am Soc Microbiol
We report the isolation of a Coccidioides immitis gene (SOWgp) which encodes an
immunodominant, spherule outer wall glycoprotein that is presented as a component of a …

Pulmonary paracoccidioidomycosis

A Restrepo, G Benard, CC de Castro… - … in respiratory and …, 2008 - thieme-connect.com
Paracoccidioidomycosis (formerly known as South American blastomycosis) is produced by
the thermally dimorphic fungus Paracoccidioides brasiliensis. Most often this mycosis runs a …

Paracoccidioidomycosis: a model for evaluation of the effects of human immunodeficiency virus infection on the natural history of endemic tropical diseases

G Benard, AJS Duarte - Clinical Infectious Diseases, 2000 - academic.oup.com
The interaction of human immunodeficiency virus (HIV) infection with endemic tropical
diseases has become a major concern, but its mechanisms are still poorly understood …

Paracoccidioides brasiliensis Disseminated Disease in a Patient with Inherited Deficiency in the β1 Subunit of the Interleukin (IL)–12/IL-23 Receptor

D de Moraes-Vasconcelos, AS Grumach… - Clinical Infectious …, 2005 - academic.oup.com
Background. Paracoccidioides brasiliensis is a facultative intracellular dimorphic fungus that
causes paracoccidioidomycosis (PCM), the most important deep mycosis in Latin America …