In basic neuroscience research, data are often clustered or collected with repeated
measures, hence correlated. The most widely used methods such as t test and ANOVA do …

Hypertension Canada's 2020 guidelines for the prevention, diagnosis, risk assessment, and
treatment of hypertension in adults and children provide comprehensive, evidence-based …

Replicability is an important feature of scientific research, but aspects of contemporary
research culture, such as an emphasis on novelty, can make replicability seem less …

We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …

Importance Extenuating circumstances can trigger unplanned changes to randomized trials
and introduce methodological, ethical, feasibility, and analytical challenges that can …

Background Intrahepatic cholestasis of pregnancy is associated with adverse perinatal
outcomes, but the association with the concentration of specific biochemical markers is …

Improving the reliability and efficiency of scientific research will increase the credibility of the
published scientific literature and accelerate discovery. Here we argue for the adoption of …

Background Interventions need to be developed prior to the feasibility and piloting phase of
a study. There are a variety of published approaches to developing interventions …

In response to limitations in the understanding and use of published evidence, evidence-
based medicine (EBM) began as a movement in the early 1990s. EBM's initial focus was on …

Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in
review currency, accuracy, and utility. We are developing a novel approach to systematic …