Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

Although it is a relatively rare disease, primarily found in the Caucasian population, uveal
melanoma is the most common primary intraocular tumor in adults with a mean age …

In patients with previously treated metastatic uveal melanoma, the historical 1 year overall
survival rate is 37% with a median overall survival of 7.8 months. We conducted a …

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Uveal melanoma represents∼ 85% of all ocular melanomas and up to 50% of patients
develop metastatic disease. Metastases are most frequently localised to the liver and, as few …

Uveal melanoma (UM) is the most common intraocular malignancy and arises from
melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is …

The overall survival (OS) of patients with metastatic uveal melanoma is short, the evidence
for effectiveness of treatments is limited, and no consensus on the choice of treatment exists …

Uveal melanoma is the most common primary malignant tumor of the eye in adults,
predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet …

Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …