Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

Significance: Exposure to ionizing radiation (IR) as the result of nuclear accidents or terrorist
attacks is a significant threat and a major medical concern. Hematopoietic stem cell (HSC) …

Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …

The tumour suppressor p53 is a central player in cellular DNA damage responses. P53 is
upregulated and activated by genotoxic stress and induces a transcriptional programme with …

PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the BH3-only
subgroup of the Bcl-2 family. It is a key mediator of p53-dependent and p53-independent …

The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after
myelosuppressive injury are not well understood. We identified epidermal growth factor …

Aberrations in the p53 tumor suppressor pathway are associated with hematologic
malignancies. p53-dependent cell cycle control, senescence, and apoptosis functions are …

Purpose: To study whether radiation-induced bleeding in the bone marrow induced iron
accumulation, and subsequently caused ferroptosis in granulocyte-macrophage …

Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate
into committed progenitors to generate all blood cells. PRDM16 is involved in human …

The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in
the intestinal crypts following irradiation but paradoxically accelerates gastrointestinal (GI) …