Burkitt lymphoma

C López, B Burkhardt, JKC Chan, L Leoncini… - Nature Reviews …, 2022 - nature.com
Burkitt lymphoma (BL) is an aggressive form of B cell lymphoma that can affect children and
adults. The study of BL led to the identification of the first recurrent chromosomal aberration …

Design and challenges of radiopharmaceuticals

K Vermeulen, M Vandamme, G Bormans… - Seminars in nuclear …, 2019 - Elsevier
This review describes general concepts with regard to radiopharmaceuticals for diagnostic
or therapeutic applications that help to understand the specific challenges encountered …

First-in-human experience of CXCR4-directed endoradiotherapy with 177Lu-and 90Y-labeled pentixather in advanced-stage multiple myeloma with extensive intra …

K Herrmann, M Schottelius, C Lapa, T Osl… - Journal of nuclear …, 2016 - Soc Nuclear Med
Chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several
types of human cancer. Based on promising experiences with a radiolabeled CXCR4 ligand …

[HTML][HTML] [68Ga] Pentixafor-PET/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma-Comparison to [18F] FDG and laboratory values

C Lapa, M Schreder, A Schirbel, S Samnick… - Theranostics, 2017 - ncbi.nlm.nih.gov
Abstract Chemokine (CXC motif) receptor 4 (CXCR4) is a key factor for tumor growth and
metastasis in several types of human cancer including multiple myeloma (MM). Proof-of …

In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma

K Philipp‐Abbrederis, K Herrmann, S Knop… - EMBO molecular …, 2015 - embopress.org
CXCR 4 is a G‐protein‐coupled receptor that mediates recruitment of blood cells toward its
ligand SDF‐1. In cancer, high CXCR 4 expression is frequently associated with tumor …

[HTML][HTML] Targeting CXCR4 in AML and all

D Cancilla, MP Rettig, JF DiPersio - Frontiers in oncology, 2020 - frontiersin.org
The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as …

18F-FDG PET dissemination features in diffuse large B-cell lymphoma are predictive of outcome

AS Cottereau, C Nioche, AS Dirand… - Journal of Nuclear …, 2020 - Soc Nuclear Med
We assessed the predictive value of new radiomic features characterizing lesion
dissemination in baseline 18F-FDG PET and tested whether combining them with baseline …

[HTML][HTML] CXCR4-directed theranostics in oncology and inflammation

M Kircher, P Herhaus, M Schottelius, AK Buck… - Annals of nuclear …, 2018 - Springer
Given its prominent role in inflammation and cancer biology, the CXC motif chemokine
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …

Molecular imaging of the chemokine receptor CXCR4 after acute myocardial infarction

JT Thackeray, T Derlin, A Haghikia, LC Napp… - JACC: Cardiovascular …, 2015 - jacc.org
Objectives: An assay for molecular imaging of myocardial CXCR4 expression was
evaluated, in order to obtain mechanistic insights noninvasively based on quantitative …

CXCR4 ligands: the next big hit?

AME Walenkamp, C Lapa, K Herrmann… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The G protein–coupled protein receptor CXC chemokine receptor 4 (CXCR4) is an attractive
target for cancer diagnosis and treatment, as it is overexpressed in many solid and …