The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

The remarkable advances coming about through nanotechnology promise to revolutionize
many aspects of modern life; however, these advances come with a responsibility for due …

The long-term investment in new approach methodologies (NAMs) within the EU and other
parts of the world is beginning to result in an emerging consensus of how to use information …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …

An adverse outcome pathway (AOP) network is an attempt to represent the complexity of
systems toxicology. This study illustrates how an AOP network can be derived and analysed …

This consensus statement voices the agreement of scientific stakeholders from regulatory
agencies, academia and industry that a new framework needs adopting for assessment of …