[HTML][HTML] Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

E Rohde, K Pachler, M Gimona - Cytotherapy, 2019 - Elsevier
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) may deliver
therapeutic effects that are comparable to their parental cells. MSC-EVs are promising …

Cell therapy in patients with heart failure: a comprehensive review and emerging concepts

R Bolli, M Solankhi, XL Tang… - Cardiovascular research, 2022 - academic.oup.com
This review summarizes the results of clinical trials of cell therapy in patients with heart
failure (HF). In contrast to acute myocardial infarction (where results have been consistently …

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

G Lanzoni, E Linetsky, D Correa… - Stem cells …, 2021 - academic.oup.com
Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality.
Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory …

Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial

A Monsel, C Hauw-Berlemont, M Mebarki, N Heming… - Critical Care, 2022 - Springer
Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced
acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived …

Mesenchymal stem cells for severe intraventricular hemorrhage in preterm infants: phase I dose-escalation clinical trial

SY Ahn, YS Chang, SI Sung… - Stem cells translational …, 2018 - academic.oup.com
We previously demonstrated that transplanting mesenchymal stem cells (MSCs) improved
recovery from brain injury induced by severe intraventricular hemorrhage (IVH) in newborn …

Human granulosa cells—stemness properties, molecular cross-talk and follicular angiogenesis

C Dompe, M Kulus, K Stefańska, W Kranc, B Chermuła… - Cells, 2021 - mdpi.com
The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and
granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs) …

Engineered extracellular vesicles-like biomimetic nanoparticles as an emerging platform for targeted cancer therapy

X Liu, C Xiao, K Xiao - Journal of Nanobiotechnology, 2023 - Springer
Nanotechnology offers the possibility of revolutionizing cancer theranostics in the new era of
precision oncology. Extracellular vesicles (EVs)-like biomimetic nanoparticles (EBPs) have …

Human Wharton's jelly—cellular specificity, stemness potency, animal models, and current application in human clinical trials

K Stefańska, K Ożegowska, G Hutchings… - Journal of Clinical …, 2020 - mdpi.com
Stem cell therapies offer a great promise for regenerative and reconstructive medicine, due
to their self-renewal and differentiation capacity. Although embryonic stem cells are …

Pathophysiology of sepsis and genesis of septic shock: the critical role of mesenchymal stem cells (MSCs)

M Daniel, Y Bedoui, D Vagner, L Raffray… - International Journal of …, 2022 - mdpi.com
The treatment of sepsis and septic shock remains a major public health issue due to the
associated morbidity and mortality. Despite an improvement in the understanding of the …

Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells

X Han, T Na, T Wu, BZ Yuan - Plos one, 2020 - journals.plos.org
BEAS-2B was originally established as an immortalized but non-tumorigenic epithelial cell
line from human bronchial epithelium. Because of general recognition for its bronchial …