Bursting microbubbles: How nanobubble contrast agents can enable the future of medical ultrasound molecular imaging and image-guided therapy
The field of medical ultrasound has undergone a significant evolution since the development
of microbubbles as contrast agents. However, because of their size, microbubbles remain in …
of microbubbles as contrast agents. However, because of their size, microbubbles remain in …
Probing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical calculations
The problem of attenuation and sound speed of bubbly media has remained partially
unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation …
unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation …
Nonlinear dynamics of acoustic bubbles excited by their pressure-dependent subharmonic resonance frequency: influence of the pressure amplitude, frequency …
Nonlinear behavior of bubbles, and most importantly 1 2 1 2-order subharmonics (SH), are
used to increase the contrast-to-tissue ratio (CTR) in diagnostic ultrasound (US) and to …
used to increase the contrast-to-tissue ratio (CTR) in diagnostic ultrasound (US) and to …
[HTML][HTML] Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components
Nanoscale ultrasound contrast agents, or nanobubbles, are being explored in preclinical
applications ranging from vascular and cardiac imaging to targeted drug delivery in cancer …
applications ranging from vascular and cardiac imaging to targeted drug delivery in cancer …
Classification of the major nonlinear regimes of oscillations, oscillation properties, and mechanisms of wave energy dissipation in the nonlinear oscillations of coated …
Acoustic waves are dissipated when they pass through bubbly media. Dissipation by
bubbles takes place through thermal damping (Td), radiation damping (Rd), and damping …
bubbles takes place through thermal damping (Td), radiation damping (Rd), and damping …
[HTML][HTML] Nonlinear power loss in the oscillations of coated and uncoated bubbles: Role of thermal, radiation and encapsulating shell damping at various excitation …
This study presents the fundamental equations governing the pressure dependent disipation
mechanisms in the oscillations of coated bubbles. A simple generalized model (GM) for …
mechanisms in the oscillations of coated bubbles. A simple generalized model (GM) for …
[HTML][HTML] Physico-mathematical model for multiple ultrasound-contrast-agent microbubbles encapsulated by a visco-elastic shell: Effect of shell compressibility on …
Y Kikuchi, T Kanagawa, T Ayukai - Chemical Engineering Science, 2023 - Elsevier
Owing to its potential for application in ultrasound-based diagnosis and therapy, the
dynamics of a microbubble encapsulated by shells has long been theoretically investigated …
dynamics of a microbubble encapsulated by shells has long been theoretically investigated …
[HTML][HTML] Weakly nonlinear propagation of focused ultrasound in bubbly liquids with a thermal effect: Derivation of two cases of Khokolov–Zabolotskaya–Kuznetsoz …
S Kagami, T Kanagawa - Ultrasonics Sonochemistry, 2022 - Elsevier
A physico-mathematical model composed of a single equation that consistently describes
nonlinear focused ultrasound, bubble oscillations, and temperature fluctuations is …
nonlinear focused ultrasound, bubble oscillations, and temperature fluctuations is …
[HTML][HTML] Nonlinear acoustic theory on flowing liquid containing multiple microbubbles coated by a compressible visco-elastic shell: Low and high frequency cases
T Kanagawa, M Honda, Y Kikuchi - Physics of Fluids, 2023 - pubs.aip.org
Microbubbles coated by visco-elastic shells are important for ultrasound diagnosis using
contrast agents, and the dynamics of single coated bubbles has been investigated in the …
contrast agents, and the dynamics of single coated bubbles has been investigated in the …
[HTML][HTML] Contribution of initial bubble radius distribution to weakly nonlinear waves with a long wavelength in bubbly liquids
T Kanagawa, R Ishitsuka, S Arai, T Ayukai - Physics of Fluids, 2022 - pubs.aip.org
In this study, the weakly nonlinear propagation of plane progressive pressure waves in an
initially quiescent liquid was theoretically investigated. This liquid contains several small …
initially quiescent liquid was theoretically investigated. This liquid contains several small …