Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Gaucher disease, the most common lysosomal storage disorder, is a heterogeneous
multisystem condition. Patients with non-neuronopathic (type 1) Gaucher disease may suffer …

Gaucher's disease continues to be a model for applications of molecular medicine to clinical
delineation, diagnosis, and treatment. Analyses of several thousand affected individuals …

Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase,
leads to prominent glucosylceramide accumulation in lysosomes of tissue macrophages …

Gaucher disease (GD), the most prevalent lysosomal storage disease, is caused by a
deficiency of glucocerebrosidase (GCase). The identification of small molecules acting as …

Extraintestinal pathogenic Escherichia coli (ExPEC) possesses virulence traits that allow it to
invade, colonize, and induce disease in bodily sites outside of the gastrointestinal tract …

The discovery of the glycosphingolipids is generally attributed to Johan LW Thudichum, who
in 1884 published on the chemical composition of the brain. In his studies he isolated …

Gaucher disease, the most common lysosomal storage disorder, is caused by the defective
activity of the lysosomal enzyme, acid‐β‐glucosidase (GlcCerase), leading to accumulation …

Abstract Taliglucerase alfa (Protalix Biotherapeutics, Carmiel, Israel) is a novel plant cell–
derived recombinant human β-glucocerebrosidase for Gaucher disease. A phase 3, double …

Cystic fibrosis is the most common life-threatening recessively inherited disease in
Caucasians. Due to early provision of care in specialized reference centers and more …