Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …

Significance: Regulation of cell adhesions during tissue repair is fundamentally important for
cell migration, proliferation, and protein production. All cells interact with extracellular matrix …

Here we provide a protocol for quantitative three-dimensional ex vivo mouse aortic ring
angiogenesis assays, in which developing microvessels undergo many key features of …

Investigations over the last decade have established the essential role of growth factors and
their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth …

Metastasis is responsible for the majority of breast cancer-related deaths. The metastatic
spread of cancer cells is a complicated process that requires considerable flexibility in the …

How individual components of the vascular basement membrane influence endothelial cell
behaviour remains unclear. Here we show that laminin α4 (Lama4) regulates tip cell …

Rationale: Integrins play a crucial role in controlling endothelial cell proliferation and
migration during angiogenesis. The Delta-like 4 (Dll4)/Notch pathway establishes an …

Integrin subunit alpha V (ITGAV), a member of integrin family of extracellular matrix
receptors, is involved in many types of cancer. In this study, the expression levels, clinical …

While integrins were originally discovered as cell adhesion receptors, recent studies have
reinforced the concept that integrins have central roles in cancer that extend far beyond …

Tetraspanins function as organizers of the cell surface by recruiting specific partner proteins
into tetraspanin-enriched microdomains, which regulate processes such as cell adhesion …