Five naturally occurring nucleolytic ribozymes have been identified: the hammerhead,
hairpin, glmS, hepatitis delta virus (HDV), and Varkud satellite (VS) ribozymes. All of these …

In many steps of gene replication and expression, RNA molecules participate as key
players, which renders them attractive targets for therapeutic intervention. While the function …

The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known
to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide …

Protein–RNA interactions play indispensable structural, catalytic, and regulatory roles within
the cell. Understanding their physical association in vivo provides valuable insight into their …

Many protein enzymes use general acid-base catalysis as a way to increase reaction rates.
The amino acid histidine is optimized for this function because it has ap K a (where K a is the …

We describe a single RNA sequence that can assume either of two ribozyme folds and
catalyze the two respective reactions. The two ribozyme folds share no evolutionary history …

Natural hammerhead ribozymes are mostly found in some viroid and viroid‐like RNAs and
catalyze their cis cleavage during replication. Hammerheads have been manipulated to act …

Hepatitis D virus (HDV) forms the genus Deltavirus unassigned to any virus family. HDV is a
satellite virus and needs hepatitis B virus (HBV) to make infectious particles. Deltaviruses …

A quantitative understanding of nucleic acid hybridization is essential to many aspects of
biotechnology, such as DNA microarrays, as well as to the structure and folding kinetics of …

A new system for recovery of rabies virus from cDNA plasmid, the transcription of which was
driven by cellular RNA polymerase II, was developed. The plasmid contains full-length viral …