Toxic metals, including excessive levels of essential metals tend to change biological
structures and systems into either reversible or irreversible conformations, leading to the …

Nickel (Ni) is known to be a major carcinogenic heavy metal. Occupational and
environmental exposure to Ni has been implicated in human lung and nasal cancers …

DNA damage is a common feature of human spermatozoa with purported links to poor rates
of conception, impaired embryonic development, an increased incidence of miscarriage and …

Apoptosis, also known as programmed cell death is a highly regulated and crucial process
found in all multicellular organisms. It is not only implicated in regulatory mechanisms of …

EFSA received a request from the Hellenic Food Authority (EFET) for a scientific opinion on
the risk to human health from the presence of nickel (Ni) in food, particularly in vegetables …

Ferroptosis is a new type of iron-dependent cell death induced by a failure of the lipid repair
protein GPX4 or the Xc-antiporter, which is essential for glutathione production. Some heavy …

Experimental induction of diabetes mellitus in animal models using chemical diabetogens is
demonstrated to impair testicular function progressively leading to decreased fertility …

Nickel, a naturally occurring element that exists in various mineral forms, is mainly found in
soil and sediment, and its mobilization is influenced by the physicochemical properties of the …

Human spermatozoa generate low levels of reactive oxygen species in order to stimulate
key events, such as tyrosine phosphorylation, associated with sperm capacitation. However …

Oxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS)
and antioxidants in the body that can cause tissue damage. Oxidative stress has a …