Molecular biology of bcr-abl1–positive chronic myeloid leukemia

A Quintás-Cardama, J Cortes - Blood, The Journal of the …, 2009 - ashpublications.org
Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …

[HTML][HTML] DNA-damage response in tissue-specific and cancer stem cells

C Blanpain, M Mohrin, PA Sotiropoulou, E Passegué - Cell stem cell, 2011 - cell.com
Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body
respond differentially to DNA damage. In this review, we will discuss how different SC …

Chronic myeloid leukaemia as a model of disease evolution in human cancer

JV Melo, DJ Barnes - Nature Reviews Cancer, 2007 - nature.com
Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

Sorting out functions of sirtuins in cancer

M Roth, WY Chen - Oncogene, 2014 - nature.com
Abstract The sirtuins (SIRT 1–7) comprise a family of NAD+-dependent protein-modifying
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

M Koptyra, R Falinski, MO Nowicki, T Stoklosa… - Blood, 2006 - ashpublications.org
Mutations in the BCR/ABL kinase domain play a major role in resistance to imatinib
mesylate (IM). We report here that BCR/ABL kinase stimulates reactive oxygen species …

Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

PV AshaRani, S Sethu, HK Lim, G Balaji… - Genome integrity, 2012 - Springer
Background Investigating the cellular and molecular signatures in eukaryotic cells following
exposure to nanoparticles will further our understanding on the mechanisms mediating …

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

U Vekariya, L Minakhin, G Chandramouly… - Nature …, 2024 - nature.com
DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand
breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular …

A matter of life and death: stem cell survival in tissue regeneration and tumour formation

D Soteriou, Y Fuchs - Nature reviews cancer, 2018 - nature.com
In recent years, great strides have been made in our understanding of how stem cells (SCs)
govern tissue homeostasis and regeneration. The inherent longevity of SCs raises the …

Mechanisms of resistance to BCR–ABL TKIs and the therapeutic strategies: A review

K Yang, L Fu - Critical reviews in oncology/hematology, 2015 - Elsevier
BCR–ABL caused by the translocation of t (9, 22) with elevated tyrosine-kinase activity could
induce leukemia in mice, which established BCR–ABL as the molecular pathogenic event in …

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells

Z Wang, H Yuan, M Roth, JM Stark, R Bhatia, WY Chen - Oncogene, 2013 - nature.com
BCR-ABL transforms bone marrow progenitor cells and promotes genome instability,
leading to development of chronic myelogenous leukemia (CML). The tyrosine kinase …