Molecular biology of bcr-abl1–positive chronic myeloid leukemia
A Quintás-Cardama, J Cortes - Blood, The Journal of the …, 2009 - ashpublications.org
Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …
[HTML][HTML] DNA-damage response in tissue-specific and cancer stem cells
C Blanpain, M Mohrin, PA Sotiropoulou, E Passegué - Cell stem cell, 2011 - cell.com
Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body
respond differentially to DNA damage. In this review, we will discuss how different SC …
respond differentially to DNA damage. In this review, we will discuss how different SC …
Chronic myeloid leukaemia as a model of disease evolution in human cancer
JV Melo, DJ Barnes - Nature Reviews Cancer, 2007 - nature.com
Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …
evolve through a multi-step process. CML is also one of the best examples of a disease that …
Sorting out functions of sirtuins in cancer
M Roth, WY Chen - Oncogene, 2014 - nature.com
Abstract The sirtuins (SIRT 1–7) comprise a family of NAD+-dependent protein-modifying
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
M Koptyra, R Falinski, MO Nowicki, T Stoklosa… - Blood, 2006 - ashpublications.org
Mutations in the BCR/ABL kinase domain play a major role in resistance to imatinib
mesylate (IM). We report here that BCR/ABL kinase stimulates reactive oxygen species …
mesylate (IM). We report here that BCR/ABL kinase stimulates reactive oxygen species …
Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells
Background Investigating the cellular and molecular signatures in eukaryotic cells following
exposure to nanoparticles will further our understanding on the mechanisms mediating …
exposure to nanoparticles will further our understanding on the mechanisms mediating …
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
U Vekariya, L Minakhin, G Chandramouly… - Nature …, 2024 - nature.com
DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand
breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular …
breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular …
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
D Soteriou, Y Fuchs - Nature reviews cancer, 2018 - nature.com
In recent years, great strides have been made in our understanding of how stem cells (SCs)
govern tissue homeostasis and regeneration. The inherent longevity of SCs raises the …
govern tissue homeostasis and regeneration. The inherent longevity of SCs raises the …
Mechanisms of resistance to BCR–ABL TKIs and the therapeutic strategies: A review
K Yang, L Fu - Critical reviews in oncology/hematology, 2015 - Elsevier
BCR–ABL caused by the translocation of t (9, 22) with elevated tyrosine-kinase activity could
induce leukemia in mice, which established BCR–ABL as the molecular pathogenic event in …
induce leukemia in mice, which established BCR–ABL as the molecular pathogenic event in …
SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
BCR-ABL transforms bone marrow progenitor cells and promotes genome instability,
leading to development of chronic myelogenous leukemia (CML). The tyrosine kinase …
leading to development of chronic myelogenous leukemia (CML). The tyrosine kinase …