The bioengineering tools have significant advantages through less time-consuming and
utilized as a promising stage for the production of pharmaceutical bioproducts under the …

In high-throughput studies of diseases, terms enriched with disease-related genes based on
Gene Ontology (GO) are routinely found. However, most current algorithms used to find …

Digitoxin has repeatedly shown to have negative effects on cancer cell viability; however,
the actual mechanism is still unknown. In this study, we investigated the effects of digitoxin (1 …

Motivation: Studying combinatorial patterns in cancer genomic datasets has recently
emerged as a tool for identifying novel cancer driver networks. Approaches have been …

The accumulation of somatic genomic alterations that enables cells to gradually acquire
growth advantage contributes to tumor development. This has the important implication of …

Objective Identifying cancer driver genes, especially rare or patient-specific cancer driver
genes, is a primary goal in cancer therapy. Although researchers have proposed some …

Synthetic viability, which is defined as the combination of gene alterations that can rescue
the lethal effects of a single gene alteration, may represent a mechanism by which cancer …

The heterogeneity of genetic alterations in human cancer genomes presents a major
challenge to advancing our understanding of cancer mechanisms and identifying cancer …

Background Over the last decade, an increasing number of integrative studies on cancer-
related genes have been published. Integrative analyses aim to overcome the limitation of a …

In recent years, C2ORF40 has been identified as a tumor suppressor gene with multiple
functions, including roles in cell proliferation, migration, and senescence. To explore the role …