Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

Pathogenesis of brain edema and investigation into anti-edema drugs

S Michinaga, Y Koyama - International journal of molecular sciences, 2015 - mdpi.com
Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …

Melatonin alleviates intracerebral hemorrhage-induced secondary brain injury in rats via suppressing apoptosis, inflammation, oxidative stress, DNA damage, and …

Z Wang, F Zhou, Y Dou, X Tian, C Liu, H Li… - Translational stroke …, 2018 - Springer
Intracerebral hemorrhage (ICH) is a cerebrovascular disease with high mortality and
morbidity, and the effective treatment is still lacking. We designed this study to investigate …

Injury mechanisms in acute intracerebral hemorrhage

DA Wilkinson, AS Pandey, BG Thompson, RF Keep… - …, 2018 - Elsevier
Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates
are increasing with an aging population. Despite an increase in research and trials of …

Spontaneous intracerebral hemorrhage

AI Qureshi, S Tuhrim, JP Broderick… - … England Journal of …, 2001 - Mass Medical Soc
Nontraumatic intracerebral hemorrhage is bleeding into the parenchyma of the brain that
may extend into the ventricles and, in rare cases, the subarachnoid space. Each year …

Mechanisms of brain injury after intracerebral haemorrhage

G Xi, RF Keep, JT Hoff - The Lancet Neurology, 2006 - thelancet.com
The past decade has resulted in a rapid increase in knowledge of mechanisms underlying
brain injury induced by intracerebral haemorrhage (ICH). Animal studies have suggested …

Ischemia-reperfusion injury in stroke

M Nour, F Scalzo, DS Liebeskind - Interventional neurology, 2013 - karger.com
Despite ongoing advances in stroke imaging and treatment, ischemic and hemorrhagic
stroke continue to debilitate patients with devastating outcomes at both the personal and …

Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema

WA Mould, JR Carhuapoma, J Muschelli, K Lane… - Stroke, 2013 - Am Heart Assoc
Background and Purpose—Perihematomal edema (PHE) can worsen outcomes after
intracerebral hemorrhage (ICH). Reports suggest that blood degradation products lead to …

[HTML][HTML] Brain edema formation and therapy after intracerebral hemorrhage

Y Wan, KG Holste, Y Hua, RF Keep, G Xi - Neurobiology of disease, 2023 - Elsevier
Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

Behavioral tests after intracerebral hemorrhage in the rat

Y Hua, T Schallert, RF Keep, J Wu, JT Hoff, G Xi - Stroke, 2002 - Am Heart Assoc
Background and Purpose—In humans, intracerebral hemorrhage (ICH) causes marked
perihematomal edema formation and neurological deficits. A rat ICH model, involving …