Objective: A role for aberrant reward processing in the pathogenesis of depression has long
been proposed. However, no review has yet examined its role in depression by integrating …

The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

Understanding the neural substrates of depression is crucial for diagnosis and treatment.
Here, we review recent studies of functional and effective connectivity in depression, in …

Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Severe symptoms of anxiety add substantial additional burden to many individuals
diagnosed with Autism Spectrum Disorder (ASD). Improved understanding of specific factors …

Aberrations in how people form expectations about rewards and how they respond to
receiving rewards are thought to underlie major depressive disorder (MDD). However, the …

The efficacy of dopamine agonists in treating major depressive disorder has been
hypothesized to stem from effects on ventrostriatal dopamine and reward function. However …

Both human and animal studies support the relationship between depression and reward
processing abnormalities, giving rise to the expectation that neural signals of these …

Background Anhedonia is hypothesized to be associated with blunted mesocorticolimbic
dopamine (DA) functioning in samples with major depressive disorder. The purpose of this …

Behavioral Activation (BA) is a contemporary third-wave psychosocial treatment approach
that emphasizes helping individuals become more active in ways that are meaningful to …