Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture,
vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute …

Inflammasomes are intracellular complexes involved in the innate immunity that convert
proIL‐1β and proIL‐18 to mature forms and initiate pyroptosis via cleaving procaspase‐1 …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside
from balloon angioplasty, bypass graft surgery is the most commonly performed …

Toll-like receptor 4 (TLR4) sensing of lipopolysaccharide (LPS), the most potent pathogen-
associated molecular pattern of gram-negative bacteria, activates NF-κB and Irf3, which …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Recent studies suggest that the heart possesses an innate immune system that is intended
to delimit tissue injury, as well as orchestrate homoeostatic responses, within the heart. The …

Atherothrombosis is a complex disease in which cholesterol deposition, inflammation, and
thrombus formation play a major role. Rupture of high-risk, vulnerable plaques is …

Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is
accomplished by the coordinated growth and remodeling of the entire uterine circulation, as …

One of the major conceptual advances in our understanding of the pathogenesis of age-
associated cardiovascular diseases has been the insight that age-related oxidative stress …