Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the
end product of an exogenous purine from food and endogenously from damaged, dying …

Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

Objective To provide guidance for the management of gout, including indications for and
optimal use of urate‐lowering therapy (ULT), treatment of gout flares, and lifestyle and other …

Since publication of the European League Against Rheumatism (EULAR) recommendations
for management of hand osteoarthritis (OA) in 2007 new evidence has emerged. The aim …

5.2. 1. Ocena funkcji skurczowej lewej komory...................................... 1052 5.2. 2. Ocena
funkcji rozkurczowej lewej komory...................................... 1052 5.2. 3. Ocena funkcji prawej …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Abstract The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice
Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical …

Gout is a picturesque presentation of uric acid disturbance. It is the most well understood
and described type of arthritis. Its epidemiology is studied. New insights into the …

Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed.
New data on imaging and clinical diagnosis have become available since the first EULAR …

Gout is a crystal-deposition disease that results from chronic elevation of uric acid levels
above the saturation point for monosodium urate (MSU) crystal formation. Initial presentation …